Use of individual containers for prostate biopsy samples: Do we gain diagnostic performance?

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• 作者：J. Panach-Navarrete ; ^{jorpanav22@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; F. Garcí ; a-Morata ; L. Valls-Gonz&aacute ; lez ; J.M. Martí ; nez-Jabaloyas
• 关键词：Prostate cancer ; Biopsy ; Diagnosis ; Gleason
• 刊名：Actas Urológicas Espa?olas (English Edition)
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：40
• 期：4
• 页码：224-228
• 全文大小：420 K

文摘

Prostate cores from transrectal biopsies are usually sent in separate vials for pathological processing. Although this is a common practice, there are controversial studies on its usefulness.

We wanted to compare the rate of prostate cancer diagnosis between processing samples in 2 containers and processing them in individual containers to see if there are differences. Our secondary objective was to check the rate of diagnosis of various tumor subtypes in each of the 2 groups.

Material and methods

A retrospective observational study was conducted of 2601 cases of prostate biopsies. Ten cores were extracted in each biopsy. We divided the sample into 2 groups: biopsies sent in 2 containers to the department of pathology (left and right lobes) or sent in 10 (one for each cylinder), according to the different criteria used in our center in the past.

We then classified the cases according to the absence of neoplasia, insignificant tumor (involvement of just 1 cylinder, <5%, Gleason score <7), Gleason 6 or Gleason ≥7. A bivariate statistical analysis was performed using the chi-squared test.

Results

A total of 1777 participants were included in the 2-container group, and 824 were included in the 10-container group. We diagnosed a rate of 32.4% of cancers in the 2-container group and 40% in the 10-container group, a difference that was statistically significant (P < 0.001).

The insignificant carcinomas were diagnosed more often in the 2-container group than in the 10-container group (6.4% vs. 4.3%, respectively; P = 0.03). Samples with a Gleason score of 6 were diagnosed more often in the 10-container group than in the 2-container group (11.9% vs. 8.1%, respectively; P = 0.002). The same occurred with the Gleason score ≥7 (23.8% in the 10-container group vs. 17.9% in the 2-container group; P < 0.001).

Conclusions

We diagnosed more prostate cancers when sending biopsied cores in individual containers. Once the procedure was conducted, we also observed in our series a reduction in the diagnoses of insignificant carcinoma to the detriment of an increased diagnosis of not insignificant carcinomas.