A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis
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- 作者：Trevor Humbya ; b ; c ; humbyt@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Ellen S. Crossb ; CrossES@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Lauren Messera ; laurenmesser94@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Silvia Guerrerod ; silvia_2i2@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; William Daviesa ; b ; c ; daviesw4@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：667-COUMATE ; Elevated plus maze ; Nephroblastoma-overexpressed ; Startle response ; Steroid sulfatase
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：363-370
- 全文大小：1241 K
文摘
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Postpartum psychosis (PP) is a severe psychiatric disorder of unknown cause.
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Steroid sulfatase (STS) deficiency may influence PP risk.
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Postpartum inhibition of STS in mice results in behavioural and genetic abnormalities.
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These abnormalities can be alleviated with an antipsychotic drug.
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The study suggests a new mouse model and a biological risk pathway for PP.