Aspergillus flavus induced alterations in tear protein profile reveal pathogen-induced host response to fungal infection

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• 作者：Jeyalakshmi Kandhavelu^a ; ¹ ; Naveen Luke Demonte^a ; ¹ ; Venkatesh Prajna Namperumalsamy^b ; Lalitha Prajna^c ; Chitra Thangavel^a ; Jeya Maheshwari Jayapal^a ; Dharmalingam Kuppamuthu^a ; ^{dharmalingam.k@gmail.com}
• 关键词：Mycotic keratitis ; Tear ; Inflammation ; Proteomics ; Glycosylation ; Complement ; NETosis ; Wound healing
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：13-21
• 全文大小：491 K
• 卷排序：152

文摘

Separation of glycosylated proteins allowed identification of more proteins in tear. Proteins of complement system and NETs were found only in patient tear. Factor H and negative regulators of MAC were also found in keratitis patient tear. Wound healing and anti-inflammatory proteins presumably counter inflammatory damage. Outcome of infection in individuals depends on the host-pathogen interaction.