Post-translational modified proteins are biomarkers of autoimmune-processes: NETosis and the inflammatory-autoimmunity connection

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• 作者：Maurizio Bruschi^b ; ¹ ; Andrea Petretto^c ; ¹ ; Roberta Bertelli^b ; Maricla Galetti^e ; Alice Bonanni^a ; Federico Pratesi^d ; Paola Migliorini^d ; Giovanni Candiano^b ; Augusto Vaglio^e ; Gian Marco Ghiggeri^a ; ^b ; ^{gmarcoghiggeri@gaslini.org}
• 关键词：Autoimmunity ; Neutrophil extracellular traps ; Citrullinated proteins ; Carbamylation ; Autoantibodies
• 刊名：Clinica Chimica Acta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：464
• 期：Complete
• 页码：12-16
• 全文大小：458 K
• 卷排序：464

文摘

Post-translational modifications of proteins are the basic step of NET formation. Modified proteins are immunogenic since they stimulate formation of autoantibodies. NET seems active in autoimmune diseases characterized by different autoantibodies. NET component characterization could clarify the pathogenesis of these diseases.