Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition
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- 作者：Masanori Miyauchia ; b ; masanori-miyauchi@ds-pharma.co.jp" class="auth_mail" title="E-mail the corresponding author ; Nichole M. Neugebauer&lrm ; a ; nichole.neugebauer@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Yoshihiro Oyamadaa ; b ; yoshihiro-oyamada@ds-pharma.co.jp" class="auth_mail" title="E-mail the corresponding author ; Herbert Y. Meltzera ; h-meltzer@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACh ; acetylcholine ; AChE ; acetylcholinesterase ; ANOVA ; analyses of variance ; AAPD ; atypical antipsychotic drug ; CIAS ; cognitive impairment associated with schizophrenia ; DA ; dopamine ; DHβE ; dihydro-β-erythroidine hydrobromide ; DI ; discrimination index ; DMSO ; dimethyl sulfoxide ; Glu ; glutamate ; HIP ; hippocampus ; ip ; intraperitoneally ; ITI ; intertrial interval ; LE ; Long&ndash ; Evans ; MEC ; mecamylamine ; mPFC ; medial prefrontal cortex ; MLA ; methyllycaconitine ; NAc ; nucleus accumbens ; nAChR ; nicotinic
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：204-212
- 全文大小：856 K
文摘
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Mecamylamine, a non-selective nAChR antagonist, induced a NOR deficit in normal rats.
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A-85380, a selective α4β2* nAChR agonist, reversed PCP-induced NOR deficit.
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PNU-282987, a selective α7 nAChR agonist, reversed PCP-induced NOR deficit.
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The reversal effect of lurasidone was blocked by mecamylamine.
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Sub-effective dose of A-85380 and PNU-282987 potentiated the effect of lurasidone.