Mecamylamine, a non-selective nAChR antagonist, induced a NOR deficit in normal rats.
A-85380, a selective α4β2* nAChR agonist, reversed PCP-induced NOR deficit.
PNU-282987, a selective α7 nAChR agonist, reversed PCP-induced NOR deficit.
The reversal effect of lurasidone was blocked by mecamylamine.
Sub-effective dose of A-85380 and PNU-282987 potentiated the effect of lurasidone.