Toll-like receptor 9 ligand D-type oligodeoxynucleotide D35 as a broad inhibitor for influenza A virus replication that is associated with suppression of neuraminidase activity
详细信息 查看全文
- 作者：Hiroshi Yamadaa ; Satoshi Nagaseb ; Kazuo Takahashic ; Yoshihiro Sakodad ; Hiroshi Kidad ; e ; Shigefumi Okamotob ; sokamoto@mhs.mp.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza A virus ; Neuraminidase inhibitors ; Oligodeoxynucleotide D35 ; G-tetrad formation ; 430-Loop in neuraminidase
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：81-92
- 全文大小：2632 K
文摘
- •
The oligodeoxynucleotide D35 suppressed replication of some influenza A viruses.
- •
D35 inhibits viral replication at the late step which is dependent on NA activity.
- •
Antiviral mechanism by D35 is different from that by oseltamivir.