Core-6 fucose and the oligomerization of the 1918 pandemic influenza viral neuraminidase
详细信息 查看全文
- 作者：Zhengliang L. Wua ; 1 ; Leon.wu@bio-techne.com" class="auth_mail" title="E-mail the corresponding author ; Hui Zhoub ; 1 ; Cheryl M. Ethena ; Vernon N. Reinholdb ; Vernon.Reinhold@unh.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza viral neuraminidase ; Core fucose ; Fucosyltransferase ; N-glycan ; Carbohydrate interaction ; Click chemistry
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：524-529
- 全文大小：990 K
文摘
- •
Expressed 1918 pandemic influenza viral neuraminidase has inactive and active forms.
- •
The inactive form contains high level of core-6 fucose, while the active form lacks such modification.
- •
Core fucose could interfere the oligomerization of the neuraminidase and thus its activation.
- •
This discovery may explain why 1918 pandemic influenza caused higher death rate among young population.