The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models
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- 作者：Yacine Abeda ; Xavier Bouhya ; Arnaud G. L&rsquo ; Huillierb ; Chantal Rhé ; aumea ; André ; s Pizzornoa ; Miguel Retamala ; Clé ; ment Fagea ; Karen Dubé ; c ; Marie-Hé ; lè ; ne Jolyc ; Edith Beaulieuc ; Corey Mallettc ; Laurent Kaiserb ; Guy Boivina ; Guy.Boivin@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza ; A(H1N1)pdm09 ; Resistance ; Neuraminidase ; E119D ; Zanamivir
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：6-12
- 全文大小：889 K
文摘
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The E119D neuraminidase (NA) mutation confers pan-resistance to NA inhibitors in A(H1N1)pdm09.
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E119D and E119D/H275Y A(H1N1)pdm09 mutants had a compromised fitness in vitro and in vivo.
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D119E reversions occurred in mutants during in vitro passages and in infected animals.