Endocannabinoid dysregulation in cognitive and stress-related brain regions in the Nrg1 mouse model of schizophrenia
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- 作者：David J. Clarkea ; b ; Jordyn Stuartc ; Iain S. McGregorc ; Jonathon C. Arnolda ; b ; c ; jonathon.arnold@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anandamide ; 2-arachidonoylglycerol ; Neuregulin 1 ; Schizophrenia ; Chronic stress ; Adolescence
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2017
- 出版时间：4 January 2017
- 年：2017
- 卷：72
- 期：Complete
- 页码：9-15
- 全文大小：883 K
文摘
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Chronic adolescent stress increased anandamide levels in the amygdala of mice.
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Nrg1 hypomorphism increased anandamide levels in the amygdala of mice.
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Nrg1 hypomorphism increased 2-AG levels in the hippocampus and reduced levels of 2-AG in the hypothalamus of mice.
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Nrg1 HET mice display impaired spatial learning as measured by the Morris Water Maze.