Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population
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- 作者：Bang-Shun Hea ; 1 ; Ling-Yun Zhangb ; 1 ; Yu-Qin Pana ; Kang Lina ; Li-Li Zhangb ; Hui-Ling Suna ; Tian-Yi Gaoa ; Tai-Qin Sub ; Shu-Kui Wanga ; shukwang@163.com" class="auth_mail" title="E-mail the corresponding author ; Cheng-Bin Zhuc ; chbinzhu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DISC1 ; Disrupted-in-Schizophrenia 1 ; NRG1 ; Neuregulin 1 ; SZ ; Schizophrenia ; SNPs ; Single nuclear polymorphisms ; EGFR ; Epidermal growth factor receptor ; MAF ; Minor allele frequencies ; OR ; Odds ratios ; CI ; Confidence interval
- 刊名：Gene
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：590
- 期：2
- 页码：293-297
- 全文大小：235 K
文摘
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A case-control study of 248 schizophrenia patients and 236 controls was performed with the Sequenom MassARRAY platform.
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Seven polymorphisms (4 in DISC1, and 3 in NRG1) were investigated the susceptibility to risk of schizophrenia.
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DISC1 rs821616 heterozygous (AT vs. AA) and co-dominant (AT/TT vs. AA) patterns were associated with increased risk for developing schizophrenia