Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus

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• 作者：Yoshihiko Yamazaki^a ; ^b ; Katumi Sumikawa^a ; ^{ksumikaw@uci.edu}
• 关键词：Nicotine ; GluN2A ; GluN2B ; Src ; Fyn ; Neuregulin 1
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：386-395
• 全文大小：1991 K
• 卷排序：113

文摘

Src selectively enhances GluN2B-NMDAR responses in naïve rats. NRG1β blocks Src-mediated enhancement of GluN2B-NMDAR responses in naive rats. NRG1β has no effect on basal GluN2B-NMDAR responses in nicotine-exposed rats. Fyn selectively enhances GluN2A-NMDAR responses in nicotine-exposed rats. NRG1β has no effect on Fyn-mediated enhancement of GluN2A-NMDAR responses.