Interleukin-6 and neuregulin-1 as regulators of utrophin expression via the activation of NRG-1/ErbB signaling pathway in mdx cells

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• 作者：Nevenka Juretić^a ; ^{njuretic@med.uchile.cl} ; Josefina Dí ; az^a ; Felipe Romero^a ; Gustavo Gonzá ; lez^a ; Enrique Jaimovich^a ; ^b ; Nora Riveros^a
• 关键词：Duchenne muscular dystrophy ; Skeletal muscle ; Myokine ; Neuregulin ; Muscle gene expression ; Dystrophin
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：770-780
• 全文大小：1917 K
• 卷排序：1863

文摘

IL-6 induces utrophin expression through NRG-1/ErbB pathway in dystrophic myotubes. Both ERK1/2 and GABPα activation are involved in utrophin expression in mdx cells. Functional relationship between IL-6 and NRG-1 as regulators of utrophin expression.