Involvement of heme oxygenase-1 induction in the cytoprotective and neuroinflammatory activities of Siegesbeckia Pubescens isolated from 5,3′-dihydroxy-3,7,4′-trimethoxyflavone in HT22 cells and BV2 cells
详细信息 查看全文
- 作者：Dong-Sung Leea ; Mina Leeb ; Sang Hyun Sungc ; Gil Saeng Jeongd ; gsjeong@kmu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Siegesbeckia pubescens ; 5 ; 3&prime ; -dihydroxy-3 ; 7 ; 4&prime ; -trimethoxyflavone ; Heme oxygenase-1 ; HT22 cells ; BV2 microglial cells
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：65-72
- 全文大小：969 K
文摘
- •
5,3′-dihydroxy-3,7,4′-trimethoxyflavone (DTMF) was isolated from S. pubescens.
- •
DTMF has neuroprotective and anti-neuroinflammatory activities.
- •
DTMF increased the HO-1 expression via Nrf2/ARE signaling in BV2 & HT22 cells.
- •
DTMF decreased microglia-mediated toxicity & primary mouse hippocampal neurons death.
- •
DTMF can be used for the prevention of functional neuronal cell damage.