Peptidomic analysis of the anterior temporal lobe and corpus callosum from schizophrenia patients

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• 作者：C.C. Café ; -Mendes^a ; E.S. Ferro^b ; A.S. Torrã ; o^a ; F. Crunfli^a ; V. Rioli^c ; A. Schmitt^d ; ^e ; P. Falkai^d ; L.R. Britto^a ; C.W. Turck^f ; D. Martins-de-Souza^g ; ^h ; ^{dmsouza@unicamp.br}
• 关键词：Schizophrenia ; Peptidomics ; Intracellular peptides ; Histone ; Anterior temporal lobe ; Corpus callosum
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：97-105
• 全文大小：444 K
• 卷排序：151

文摘

Natural Intracellular peptides were differentially expressed in ATL and CC of schizophrenia patients and healthy controls. Peptide fragments from neurogranin were altered in ATL and CC of schizophrenia patients. A histone H2B type 1-H peptide fragment was differentially expressed in ATL of schizophrenia patients. The fragment of histone H2B type 1-H was tested in Neuro2a cells and presented a promising cytoprotective effect. The results add evidence to the biological significance of endogenous intracellular peptides.