Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression

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• 作者：Sze Yen Kerk¹ ; Paschalis Kratsios¹ ; ² ; ^{pkratsios@uchicago.edu} ; Michael Hart¹ ; Romulo Mourao¹ ; Oliver Hobert¹ ; ³ ; ^{or38@columbia.edu}
• 关键词：neuron diversification ; motor neuron ; neuron subtype ; selective repression ; combinatorial code ; transcription factor ; terminal selector ; repressor ; maintenance ; C. elegans
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：80-98
• 全文大小：4093 K
• 卷排序：93

文摘

Unique combinations of class-specific repressors define motor neuron classes Repressors counteract terminal selector-driven gene activation in distinct classes Repression is achieved via repressor binding sites adjacent to the activator site Repressors are continuously required throughout life to maintain class identity