Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells
详细信息 查看全文
- 作者：Mü ; cahit Seç ; mea ; Canan Eroğlub ; Yavuz Dodurgaa ; yavuzdodurga@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Gü ; lseren Bağcıa
- 关键词：NB ; Neuroblastoma ; OLE ; Oleuropein ; XTT ; [2 ; 3-Bis-(2-methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide] ; TUNEL ; mediated deoxyuridine triphosphate (dUTP)-digoxigenin nick-end labeling ; CDK ; Cyclin dependent kinase ; DMSO ; dimethylsulfoxide ; HT ; Hydroxytyrosol
- 刊名：Gene
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：585
- 期：1
- 页码：93-99
- 全文大小：1054 K
文摘
- •
Oleuropein is inhibiting cell proliferation in SH-SY5Y neuroblastoma cells by inducing cell cycle arrest via genes expression changes of CCND1,CCND2, CDK4, CDK6,p53 and CDK inhibitors.
- •
Oleuropein is stimulating apoptotic mechanisms in SH-SY5Y via intrinsic pathway.
- •
Oleuropein is decreasing invasion, migration and colony formation in SH-SY5Y neuroblastoma cells.