• 作者：Karen C.L. Torres^a ; ^d ; ¹ ; Giselle Lima^a ; ¹ ; Ana C. Simõ ; es e Silva^b ; Isabela Lubambo^a ; Luiz O. Rodrigues^c ; Luiza Rodrigues^c ; Ká ; tia D. Silveira^b ; É ; rica L.M. Vieira^b ; Marco A. Romano-Silva^a ; Dé ; bora M. Miranda^a ; ^{debora.m.miranda@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：APC ; Allophycocyanin ; IL-1β ; interleukin-1 beta ; IL-6 ; interleukin-6 ; IL-8 ; interleukin-8 ; IL-10 ; interleukin-10 ; IL-17 ; interleukin-17 ; INF ; interferon ; IP-10 ; interferon-gamma inducible ; GTP ; guanosine triphosphate ; MW ; Mann&ndash ; Whitney ; MCP-1 ; monocyte chemoattractant protein-1 ; NF1 ; neurofibromatosis type 1 ; MPNST ; malignant peripheral nerve sheath tumor ; PBMCs ; peripheral blood mononuclear cells ; PE ; phycoerythrin ; PNF ; plexiform neurofibroma ; MAPK ; MAP-kinase ; TGF-β ; transforming growth
• 刊名：Journal of Neuroimmunology
• 出版年：2016
• 出版时间：15 June-15 July 2016
• 年：2016
• 卷：295-296
• 期：Complete
• 页码：122-129
• 全文大小：951 K

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Little is known about the immunesurveillance of neurofibromatosis type 1 (NF1).

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There is an increased frequency of cells expressing anti-inflammatory cytokines.

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There is a decreased frequency of cells expressing inflammatory cytokines.

Neurofibromatosis type 1 (NF1) is a monogenetic disorder with an early mortality determined mostly by malignancy. This study evaluated inflammatory markers and their cellular sources in NF1 patients to try understanding the relation of immune factors and the tumorigenesis that characterizes the disease. Anti-inflammatory profile was observed in cells expressing cytokines, except for a small subpopulation of CD8 + T cells that displayed an increased frequency of cells expressing the pro-inflammatory cytokine Tumor necrosis factor (TNF-α), while plasma soluble levels of Transforming growth factor-beta (TGF-β) and interleukin-6 (IL-6) were increased in NF1 patients. Knowledge of the regulation of NF1 and the role of TGF-beta signaling pathway in malignant peripheral nerve sheath tumor pathogenesis might shed light on molecular carcinogenesis mechanisms and lead to putative interventions both in prevention and treatment of malignant tumors.