Lysine-specific demethylase-1 (LSD1) is compartmentalized at nuclear chromocenters in early post-mitotic cells of the olfactory sensory neuronal lineage
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- 作者：Seda Kilinca ; 1 ; skilinc@wesleyan.edu" class="auth_mail" title="E-mail the corresponding author ; Alyssa Savarinoa ; 1 ; Julie H. Colemanb ; James E. Schwobb ; Robert P. Lanea ; rlane@wesleyan.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Olfactory receptor genes ; LSD1/KDM1A ; Neurogenin ; p27Kip1 ; H3K9 methylation ; Chromocenters ; Compartmentalization
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：58-70
- 全文大小：1784 K
文摘
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LSD1 forms a single compartment in early post-mitotic cells of the OSN lineage.
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LSD1 complexes with CoREST in early G1 of an immortalized olfactory cell line.
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One or a small number of OR gene loci interact with the LSD1 compartment per cell.
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20">OR loci appear decondensed but are not transcribed from within LSD1 compartments.
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25">Histone demethylation activity appears to be limited within LSD1 compartments.