MITIGATION OF THE SOMNOLENCE OF INSULIN-INDUCED HYPOGLYCEMIA BY A VASOPRESSIN V₁ RECEPTOR ANTAGONIST IN THE RHESUS MONKEY

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• 作者：Chen ; Ming-Dao ; Ö ; rdö ; g ; Tamá ; s ; Knobil ; Ernst
• 关键词：Insulin-induced hypoglycemia ; Neuroglycopenia ; Somnolence ; Vasopressin ; V₁ receptor antagonist ; Rhesus monkey
• 刊名：Psychoneuroendocrinology
• 出版年：1998
• 出版时间：July, 1998
• 年：1998
• 卷：23
• 期：5
• 页码：497-503
• 全文大小：80.4 K

文摘

Insulin-induced hypoglycemia causes somnolence in rhesus monkeys, a phenomenon usually considered an aspecific consequence of neuroglycopenia. Previous observations from our laboratory have raised the possibility that arginine vasopressin (AVP) may also play a role in this decrease in wakefulness. In the present study we tested this hypothesis by inducing hypoglycemia (40 mg/dl) in ovariectomized rhesus monkeys by intravenous administration of insulin in the presence of continuous intracerebroventricular infusions of the V₁ receptor antagonist [deamino-Pen¹,O-Me-Tyr²,Arg⁸]-vasopressin (180 μg/60 μl per h) or of its vehicle alone (artificial cerebrospinal fluid, 60 μl/h). Wakefulness was assessed by a scoring system by observers blinded to the experimental protocol. The AVP antagonist significantly attenuated the decrease in wakefulness observed in response to insulin-induced hypoglycemia (p<.03) without increasing blood glucose levels. These and previous findings suggest that the somnolence induced by a moderate degree of hypoglycemia may not entirely be the direct consequence of neuroglycopenia and that AVP may, directly or indirectly, be involved.