Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer’s disease spectrum
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- 作者：Ashley Swansona ; 1 ; A.A. Willettea ; b ; c ; 1 ; awillett@iastate.edu" class="auth_mail" title="E-mail the corresponding author ; for the Alzheimer&rsquo ; s Disease Neuroimaging Initiative2
- 关键词：Alzheimer&rsquo ; s disease ; Medial temporal lobe ; Inflammation ; Immunology ; Amyloid ; Tau ; Memory ; Biomarkers ; NPTX2 ; C3LP1
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：201-208
- 全文大小：1905 K
文摘
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Synapse plasticity and microglial markers best predict Alzheimer’s disease outcomes.
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NPTX2 predicts 28.7% and 56% of MTL atrophy and memory decline by 24 months.
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C3LP1 predicts 8.3% of MTL atrophy over time, but not memory decline by 24 months.