Structural imaging of hippocampal subfields in healthy aging and Alzheimer鈥檚 disease
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- 作者：Robin de Flores&dagger ; ; Renaud La Joie ; &dagger ; ; lajoie@cyceron.fr" class="auth_mail" title="E-mail the corresponding author ; Gaë ; l Ché ; telat
- 关键词：AD ; Alzheimer&rsquo ; s disease ; ADNI ; Alzheimer&rsquo ; s Disease Neuroimaging Initiative ; ASHS ; Automatic Segmentation of Hippocampal Subfields ; A尾 ; amyloid beta ; DG ; dentate gyrus ; MCI ; mild cognitive impairment ; MRI ; magnetic resonance imaging ; NFT ; neurofibrillary tangle ; VBM ; Voxel Based Morphometry
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：19 November 2015
- 年：2015
- 卷：309
- 期：Complete
- 页码：29-50
- 全文大小：1236 K
文摘
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Hippocampal subfield structure can be assessed in vivo with (high-resolution) MRI.
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AD-related atrophy is initially focal (in CA1) before spreading to other subfields.
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This pattern of atrophy could be a sensitive biomarker for early AD detection.
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The effect of age and specific memory–volume correlations are less clear.
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Variations in methods and segmentation protocols cause important discrepancies.