Reproducibility of hippocampal atrophy rates measured with manual, FreeSurfer, AdaBoost, FSL/FIRST and the MAPS-HBSI methods in Alzheimer's disease
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- 作者：Keith S. Covera ; keith@kscover.ca" class="auth_mail" title="E-mail the corresponding author ; Ronald A. van Schijndela ; Adriaan Versteega ; Kelvin K. Leungb ; Emma R. Muldera ; Remko A. Jonga ; Peter J. Vissera ; Alberto Redolfic ; Jerome Revillardd ; Baptiste Grenierd ; David Mansetd ; Soheil Damangire ; Paolo Boscoc ; Hugo Vrenkena ; Bob W. van Dijka ; Giovanni B. Frisonic ; f ; Frederik Barkhofa ; for the Alzheimer's Disease Neuroimaging Initiative ; neuGRID1
- 关键词：Hippocampus ; Atrophy ; Manual segmentation ; Automatic segmentation ; Magnetic resonance imaging ; Mild cognitive impairment ; Alzheimer disease ; Boundary shift integral
- 刊名：Psychiatry Research: Neuroimaging
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：252
- 期：Complete
- 页码：26-35
- 全文大小：747 K
文摘
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Compared the reproducibility of methods for measuring hippocampal atrophy rates.
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Compared FreeSurfer, FSL/FIRST, MAPS-HBSI, AdaBoost and manual.
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Back-to-back MPRAGEs at baseline and year one for N=562 ADNI1 1.5 T subjects.
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Used a novel but simple statistical test that is robust to outlying data points.
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MAPS-HBSI should require half the subjects in a clinical trial than others tested.