Preconditioning ischemia attenuates increased neurexin–neuroligin1–PSD-95 interaction after transient cerebral ischemia in rat hippocampus

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• 作者：Chong Li ; Dong Han ; Fa Zhang ; Cui Zhou ; Hong-Min Yu ; Guang-Yi Zhang
• 关键词：Ischemia ; Neurexin ; Neuroligin1 ; PSD-95 ; Preconditioning ; NMDA receptor
• 刊名：Neuroscience Letters
• 出版年：2007
• 出版时间：22 October 2007
• 年：2007
• 卷：426
• 期：3
• 页码：192-197
• 全文大小：657 K

文摘

In this study, we investigated the interactions between synapse adhesion molecules neurexin, neuroligin1, neuroligin2 and postsynaptic density protein 95 (PSD-95) in transient cerebral ischemia and possible regulatory mechanism of these interactions. Our data show that preconditioning ischemia can down-regulate the increased neurexin–neuroligin1–PSD-95 interaction induced by ischemia injury and exerts a neuroprotective effect. Pre-treatment of N-methyl-d-aspartate (NMDA) receptor antagonist ketamine can demolish this neuroprotective effect of preconditioning by increasing neurexin–neuroligin1–PSD-95 interaction. These results indicate that the neurexin–neuroligin1–PSD-95 is an important signalling module in ischemic injury and a novel possible target in therapeutics of brain ischemia.