Environmental, dietary and case-control study of Nodding Syndrome in Uganda: A post-measles brain disorder triggered by malnutrition?
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- 作者：Peter S. Spencera ; b ; c ; d ; spencer@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Rajarshi Mazumdera ; 1 ; Valerie S. Palmera ; b ; d ; Michael R. Lasarevc ; Ryan C. Stadnika ; 2 ; Peter Kinga ; 3 ; Margaret Kabahendae ; David L. Kitarac ; Diane Stadlerf ; Breanna McArdleg ; James K. Tumwineh ; other Members of the Oregon-Uganda Nodding Syndrome Research Team4
- 关键词：Tropical neurology ; Internment ; Infection ; Moldy food ; Epilepsy ; Sub-acute sclerosing panencephalitis (SSPE) ; Abnormal sleep ; Cognitive deficits
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：369
- 期：Complete
- 页码：191-203
- 全文大小：1075 K
文摘
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Nodding Syndrome Cases had higher rates than Community Controls of prior measles infection and moldy food before onset
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High Case-onset months aggregated across years corresponded to periods of low crop production and food shortages
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Peaks of epidemic Nodding Syndrome (2003-08) followed an epidemic of measles (1998–2002)
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NS has clinical features comparable to post-measles subacute sclerosing panencephalitis (SSPE)
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Onchocerciasis is likely a NS bystander, causally unrelated to the neurological disease