文摘
Synthesis of 6,7-dihydro-[1,3,4]thiadiazolo[3,2-a] [1,3]diazepines. Compounds GS-53 (30) and AAH1 (33) induced neuromuscular blockade. Compound 30 proved to be as twice as potent as 33 with rapid onset and shorter duration. Recognition with Thr120 and Thr124 at α7β2 nAChR receptor is essential for activity.