Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2
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- 作者：R. Rumpela ; &dagger ; ; O. Barona ; &dagger ; ; &Dagger ; ; A. Ratzkaa ; &dagger ; ; M.-L. Schrö ; dera ; b ; M. Hohmanna ; A. Effenberga ; P. Clausa ; b ; C. Grothea ; b ; grothe.claudia@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：BSA ; bovine serum albumin ; DA ; dopaminergic ; DAT ; dopamine transporter ; DIV ; days in vitro ; DMSO ; dimethyl sulfoxide ; E ; embryonic day ; ERK ; extracellular signal-regulated kinase ; FB ; forebrain ; FGF ; fibroblast growth factor ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; HMW ; high molecular weight ; ko ; knock-out ; LMW ; low molecular weight ; NGS ; normal goat serum ; OD ; optical density ; P ; postnatal day ; PBS ; phosphate-buffered saline ; PFA ; paraformaldehyde ; PFC ; prefrontal cortex ; PVD
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：134-144
- 全文大小：2195 K
文摘
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Lack of FGF-2-LMW is most feasible for misdevelopment of the nigrostriatal system.
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FGF-2-deficient mice showed increased volume of the dopaminergic forebrain target.
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Blocking the canonical FGFR mimics enlarged forebrain innervation in explants.
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FGFR-mediated ERK activation is responsible for adequate forebrain innervation.