Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice
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- 作者：Chang Liua ; 1 ; Youxuan Wua ; 1 ; Shuai Zhaa ; Mengping Liua ; Ying Wanga ; Guangde Yangb ; Kaige Maa ; Yulang Feic ; Yaojie Zhangd ; Xiaodan Hua ; Weina Yanga ; wn_yang@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yihua Qiana ; qianyh38@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aβ ; β-amyloid ; ACh ; acetylcholine ; AChE ; acetylcholinesterase ; ACSF ; artificial cerebral spinal fluid ; AD ; Alzheimer&rsquo ; s disease ; ANOVA ; analysis of variance ; CA1 ; hippocampal cornu ammonis 1 ; ECL ; enhanced chemiluminescence ; GSH-Px ; glutathione peroxidase ; ICV ; intracerebroventricular ; MAPK ; mitogen activated protein kinase ; MDA ; malondialdehyde ; MWM ; Morris water maze ; PFA ; paraformaldehyde ; PVDF ; polyvinylidene difluoride ; SDS ; sodium dodecyl sulfate ; STZ ; streptozotocin ; SOD ; superoxide
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1631
- 期：Complete
- 页码：137-146
- 全文大小：4536 K
文摘
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ICV injection of STZ prominently impairs learning and memory ability in mice.
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Tan IIA protects the neurons from STZ induced damage.
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Tan IIA restores AChE activity in the parietal cortex and hippocampus.
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Tan IIA attenuates oxidative stress in the parietal cortex and hippocampus.
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Tan IIA blocks p38 MAPK pathway activation in the parietal cortex and hippocampus.