Lentivirus-mediated PGC-1α overexpression protects against traumatic spinal cord injury in rats
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- 作者：Jianzhong Hua ; Ye Langa ; Tao Zhangb ; Shuangfei Nia ; Hongbin Lub ; hongbinlu@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; 5-hydroxytryptamine ; BBB scores ; Basso&ndash ; Beattie&ndash ; Bresnahan Locomotor Rating Scale ; CNS ; central nervous system ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; eGFP ; enhanced green fluorescence protein ; GAP43 ; growth-associated protein 43 ; LV-eGFP ; lentiviral vector that only expressed eGFP ; PBS ; phosphate-buffered saline ; PGC-1α ; peroxisome proliferator-activated receptor-γ coactivator-1 alpha ; PVDF ; polyvinylidene difluoride ; qRT-PCR ; quantitative real-time polymerase chain reaction
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：328
- 期：Complete
- 页码：40-49
- 全文大小：2184 K
文摘
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Intraspinal injection of lentiviral vectors leads to PGC-1α overexpression.
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PGC-1α overexpression attenuates neuronal apoptosis following SCI.
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PGC-1α overexpression increases potential of axonal regeneration following SCI.
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PGC-1α overexpression promotes hindlimb motor functional recovery following SCI.
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PGC-1α overexpression may mediate inhibition of the RhoA–ROCK pathway following SCI.