Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens
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- 作者：Enoch Nga ; b ; Rafael K. Varaschinc ; Ping Sue ; Caleb J. Browned ; e ; Joanna Hermainskif ; Bernard Le Folle ; h ; Olaf Pongsg ; Fang Liue ; h ; Louis-Eric Trudeauc ; John C. Rodera ; i ; Albert H.C. Wonge ; h ; albert.wong@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuronal calcium sensor-1 ; Frequenin ; Motivation ; Dopamine ; Effort ; Progressive ratio
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：213-225
- 全文大小：3447 K
文摘
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Neuronal calcium sensor-1 knockout mice were characterized.
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10">Knockout mice are less willing to work for food.
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15">Knockout brain slices show lower nucleus accumbens core dopamine release.
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Food preference, Pavlovian incentive learning and sensory-specific satiety are normal.
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Locomotion, amphetamine-induced hyperlocomotion and sensitization are normal.