Norepinephrine-induced calcium signaling in astrocytes in the respiratory network of the ventrolateral medulla
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- 作者：Christian Schnella ; c ; 1 ; Mahmoud Negmb ; 1 ; Johannes Driehausb ; Anja Schellerd ; Swen Hü ; lsmanna ; b ; shuelsm2@uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glia ; Catecholaminergic signaling ; Neuronal control of breathing
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：226
- 期：Complete
- 页码：18-23
- 全文大小：1635 K
文摘
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Norepinephrine modulates calcium signaling in astrocytes of the respiratory network.
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10">Norepinephrine acts via the G protein coupled Phospholipase C-Inositol trisphosphate cascade (Gq-PLC-IP3).
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15">Astrocytes that express the genetically encoded calcium sensor GCaMP3 controlled by the Glast locus allow unequivocal identification of astrocytic calcium signals.
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Norepinephrine-induced signaling in astrocytes has to be considered a key modulator of neuronal activity in the respiratory network.