Phosphorylation Signals in Striatal Medium Spiny Neurons

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• 作者：Taku Nagai¹ ; Junichiro Yoshimoto² ; Takayuki Kannon³ ; Keisuke Kuroda⁴ ; Kozo Kaibuchi⁴ ; ^{kaibuchi@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：database ; dopamine ; excitability ; phosphoproteomics ; protein kinase A ; reward-associated behaviors
• 刊名：Trends in Pharmacological Sciences
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：37
• 期：10
• 页码：858-871
• 全文大小：2911 K

文摘

Dopamine signaling in the brain is a complex phenomenon that strongly contributes to emotional behaviors. Medium spiny neurons (MSNs) play a major role in dopamine signaling through dopamine D1 receptors (D1Rs) or dopamine D2 receptors (D2Rs) in the striatum. cAMP/protein kinase A (PKA) regulates phosphorylation signals downstream of D1Rs, which affects the excitability of MSNs, leading to reward-associated emotional expression and memory formation. A combination of phosphoproteomic approaches and the curated KANPHOS database can be used to elucidate the physiological and pathophysiological functions of dopamine signaling and other monoamines. Emerging evidence from these techniques suggests that the Rap1 pathway plays a crucial role in the excitability of MSNs, leading to the expression of emotional behaviors.