Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning
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- 作者：Hau-Jie Yau1 ; 8 ; Dong V. Wang2 ; Jen-Hui Tsou1 ; Yi-Fang Chuang3 ; Billy T. Chen1 ; 9 ; Karl Deisseroth4 ; 5 ; Satoshi Ikemoto2 ; Antonello Bonci1 ; 6 ; 7 ; 10 ; antonello.bonci@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：pedunculopontine tegmental nucleus ; PPTg ; ventral tegmental area ; VTA ; appetitive Pavlovian conditioning ; VTA non-DA neurons ; cholinergic input ; glutamatergic input
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2699-2710
- 全文大小：3884 K
文摘
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We study how VTA afferent inputs modulate appetitive Pavlovian conditioning
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PPTg-to-VTA excitatory inputs are required for proper cue-reward association
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PPTg-to-VTA excitatory inputs support non-DA neural activity in vivo
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VTA non-DA neural activity is necessary for appetitive Pavlovian conditioning