To our knowledge, this is the first documentation of relapsing-remitting facial and brachial plexus neuritis caused by recurrent reactivation of HSV-1.

The recurrent multifocal peripheral neuronal involvement argues for an immune-mediated polyneuropathy, but the stereotype neurological symptoms confined to the same anatomical areas during each episode, and with short latency of HSV-1 reactivation, favor an infectious neuropathy.

Mannose-binding lectin deficiency (MBL) is associated with recurrent infections, but the role in patients with recurrent HSV-1 reactivation is still not known.