The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD)
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- 作者：Magdy El-Salhya ; b ; c ; magdy.el-salhy@helse-fonna.no" class="auth_mail" title="E-mail the corresponding author ; Trygve Hauskenb ; c ; Trygve.hausken@helse-bergen.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：Crohn's disease ; Inflammatory bowel disease ; Motility ; Secretion ; Ulcerative colitis
- 刊名：Neuropeptides
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：137-144
- 全文大小：1417 K
文摘
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All members of the NPY family are abnormal in both patients with IBD and animal models of human IBD.
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The abnormality in NPY appears to be a primary factor contributing to IBD, and is caused by interaction between immune cells and NPY neurons in the enteric nervous system during inflammation.
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Abnormalities in PYY and PP seem to be secondary to the changes caused by abnormalities in other gut neurohormonal peptides/amines during inflammation.