Widespread alterations in the synaptic proteome of the adolescent cerebral cortex following prenatal immune activation in rats
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- 作者：Balá ; zs A. Gyö ; rffya ; b ; Pé ; ter Gulyá ; ssyc ; d ; Barbara Gellé ; na ; e ; Katalin Vö ; lgyia ; e ; Dó ; ra Madarasia ; Viktor Kisf ; Olivé ; r Ozohanicsc ; Ildikó ; Pappg ; Pé ; ter Ková ; csg ; Gert Lubecd ; Á ; rpá ; d Dobolyie ; Jó ; zsef Kardosb ; Lá ; szló ; Drahosc ; Gá ; bor Juhá ; sza ; c ; Katalin A. Ké ; kesia ; h ; kakekesi@ttk.elte.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Maternal immune activation (MIA) ; Schizophrenia ; Autism spectrum disorder (ASD) ; Cerebral cortex ; Neuroproteomics ; Synaptosome
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：289-309
- 全文大小：4682 K
文摘
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First study examining synaptic proteome changes due to prenatal immune activation.
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Presynaptic molecular mechanisms are more affected than postsynaptic ones.
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Several basic and synaptic cellular functions are influenced.
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Camk2a is downregulated in the prefrontal cortex.
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Our data show widespread overlap with schizophrenia- and autism-related molecules.