Neuropsychological functioning and chronic methadone use: A systematic review and meta-analysis

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• 作者：A. Baldacchino^a ; ^{amb30@st-andrews.ac.uk} ; M. Armanyous^c ; ^{m.armanyous@nhs.net} ; D.J.K. Balfour^b ; ^{d.j.k.balfour@dundee.ac.uk} ; G. Humphris^a ; ^{gmh4@st-andrews.ac.uk} ; K. Matthews^b ; ^{k.matthews@dundee.ac.uk}
• 关键词：Opioid dependence ; Cognitive impairments ; Methadone ; Abstinence ; Meta-analysis
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：23-38
• 全文大小：1561 K
• 卷排序：73

文摘

A broad range of domains of neuropsychological performance are significantly impaired in studies which have compared methadone populations with the healthy controls. However low power, poor quality and heterogenous populations limit the interpretation of these results. Short term (less than 1 year) abstinent groups, when compared with methadone groups, still exhibited cognitive impairments but results are inconclusive. It is still not clear what the role of global sedative effects of opioids such as methadone have on cognitive impairment. Only higher quality longitudinal studies using ecologically valid cognitive tests, in well-defined population groups can address this question. Methadone populations present with a broad range of neuropsychological impairment when compared with healthy controls.