Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism
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- 作者：Soon-Gu Kwona ; Seo-Yeon Yoonb ; c ; Dae-Hyun Rohd ; Sheu-Ran Choia ; Hoon-Seong Choia ; Ji-Young Moone ; Suk-Yun Kange ; Alvin J. Beitzf ; Jang-Hern Leea ; jhl1101@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neurosteroid ; Dehydroepiandrosterone sulphate ; Pregnenolone sulfate ; P2X ; Sigma-1 receptor ; Mechanical allodynia
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：227-232
- 全文大小：1308 K
文摘
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Intraplantar injection of neurosteroids alone does not cause mechanical allodynia.
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DHEAS or PREGS potentiates P2X receptor mediated mechanical allodynia.
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Action of neurosteroids is mediated by sigma-1 but not GABAA or NMDA receptors.