Cytokines in cerebrospinal fluid of neurosyphilis patients: Identification of Urokinase plasminogen activator using antibody microarrays
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- 作者：Ping Lua ; 1 ; Dao-Cheng Zhenga ; 1 ; Chang Fangb ; Jin-Mei Huanga ; Wu-Jian Kea ; Liu-Yuan Wanga ; Wei-Ying Zenga ; He-Ping Zhenga ; Bin Yanga ; yangbin101@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Syphilis ; Cerebrospinal fluid (CSF) ; Urokinase plasminogen activator (uPA) ; Neurosyphilis
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：293
- 期：Complete
- 页码：39-44
- 全文大小：655 K
文摘
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We examine the 507 proteins in the CSF of neurosyphilis patients through Protein Microarray Assay.
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The highly elevated CSF uPA levels are strongly associated with neurosyphilis.
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There was no significant difference in uPA serum concentrations between neurosyphilis patients and syphilis patients without neural involvement, which suggests that the increased CSF uPA levels in neurosyphilis patients reflect enhanced synthesis by cells in the brain.