Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding
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- 作者：Robert P. Sparksa ; Jermaine L. Jenkinsb ; Gregory E. Minera ; Yan Wanga ; Wayne C. Guidac ; Charles E. Sparksd ; Rutilio A. Frattia ; Janet D. Sparksd ; Janet_Sparks@urmc.rochester.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sortilin ; VLDL-B100 ; Neurotensin ; Surface plasmon resonance
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：479
- 期：3
- 页码：551-556
- 全文大小：1426 K
文摘
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PIP3 theoretically binds to the C-terminal neurotensin binding site on sortilin.
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PIP3 nanodiscs bind to sortilin.
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diC4 PIP3 competes for neurotensin binding to sortilin.
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Immunoreactive PIP3 is present on rat plasma VLDL.
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A sortilin binding compound enhances neurotensin and PIP3 binding to sortilin.