Role of glutamate receptors in tetrabrominated diphenyl ether (BDE-47) neurotoxicity in mouse cerebellar granule neurons
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- 作者：Lucio G. Costaa ; b ; lgcosta@u.washington.edu" class="auth_mail" title="E-mail the corresponding author ; Sara Tagliaferria ; b ; Pamela J. Roqué ; a ; Claudia Pellacanib
- 关键词：Flame retardants ; BDE-47 ; Developmental neurotoxicity ; Glutamate receptors ; NMDA ; AMPA/Kainate
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：241
- 期：Complete
- 页码：159-166
- 全文大小：1058 K
文摘
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Toxicity of BDE-47in cerebellar granule neurons is decreased by antagonists of ionotropic glutamate receptors.
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BDE-47 increases intracellular calcium and causes oxidative stress.
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These effects of BDE-47 appear to be secondary to an increase of extracellular glutamate.