Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism

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• 作者：Grant Kauwe¹ ; ⁴ ; Kazuya Tsurudome¹ ; ² ; ⁴ ; Jay Penney² ; Megumi Mori¹ ; Lindsay Gray¹ ; Mario R. Calderon¹ ; Fatima Elazouzzi² ; Nicole Chicoine¹ ; Nahum Sonenberg³ ; A. Pejmun Haghighi¹ ; ² ; ⁵ ; ^{phaghighi@buckinstitute.org}
• 关键词：Homeostatic synaptic plasticity ; Retrograde signaling ; 4E-BP ; Fasting ; Regulation of Neurotransmitter release ; postsynaptic translation ; mTOR
• 刊名：Neuron
• 出版年：2016
• 出版时间：21 December 2016
• 年：2016
• 卷：92
• 期：6
• 页码：1204-1212
• 全文大小：2300 K
• 卷排序：92

文摘

Acute fasting inhibits homeostatic synaptic compensation at the NMJ Muscle 4E-BP, under the transcriptional control of FOXO, is responsible for this block Postsynaptic 4E-BP also modulates baseline synaptic transmission A balance between postsynaptic TOR and 4E-BP adjusts synaptic strength