Maternal obesity alters brain derived neurotrophic factor (BDNF) signaling in the placenta in a sexually dimorphic manner

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• 作者：Calais S. Prince^a ; ^{princec@livemail.uthscsa.edu} ; Alina Maloyan^a ; ^b ; Leslie Myatt^a ; ^c
• 关键词：Placenta ; Obesity ; microRNA ; Neurotrophin ; Sexual dimorphism
• 刊名：Placenta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：55-63
• 全文大小：1723 K
• 卷排序：49

文摘

Validation of increased placental miR-210 from obese women carrying a female fetus. Decreased placental BDNF in obese women carrying a female fetus. Decreased placental proBDNF in obese women carrying a male fetus. Decreased placental mature BDNF from male fetuses, independent of maternal BMI. Dysregulated placental TRKB and MAPK signaling with maternal obesity.