Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury
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- 作者：Anuradha Kalani ; MS ; PhDa ; a0kala02@louisville.edu" class="auth_mail" title="E-mail the corresponding author ; Pankaj Chaturvedia ; Pradip K. Kamata ; Claudio Maldonadoa ; b ; Philip Bauerb ; Irving G. Joshuaa ; Suresh C. Tyagia ; Neetu Tyagia
- 关键词：AchE ; acetylcholinestrase ; BBB ; blood brain barrier ; BSA ; bovine serum albumin ; cDNA ; complimentary DNA ; DAPI ; 4 ; 6-diamidino-2-phenyl-indole HCl ; FIU ; fluorescence intensity units ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GFAP ; glial fibrillary acidic protein ; ICAM ; intra cellular adhesion molecule-1 ; IHC ; Immunohistochemistry ; IR ; Ischemia Reperfusion ; LEA ; Lycopersicon Esculentum agglutinin tomato lectin ; LPS ; Lipopolysaccharide ; MESC-exo ; Mouse embryonic stem cell exosomes ; MESC-exocu
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：79
- 期：Complete
- 页码：360-369
- 全文大小：2271 K
文摘
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This is the important study that describes the combined therapeutic potentials of curcumin and embryonic stem cell exosomes.
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Stem cells have rejuvenating properties and curcumin possesses anti-inflammatory, anti-lipidemic and neurorestoration properties.
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The combined therapeutic units reduced ischemic injury and restored neuro-vascular unit following ischemia-reperfusion injury in mice.