Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions
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- 作者：Natalya L. Teterina ; Guangping Liu ; Olga A. Maximova ; Alexander G. Pletnev ; apletnev@niaid.nih.gov" class="auth_mail
- 关键词：Flavivirus ; Micrornas ; Neuropathogenesis
- 刊名：Virology
- 出版年：May 2014
- 年：2014
- 卷：456-457
- 期：Complete
- 页码：247-258
- 全文大小：11952 K
文摘
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Generated neurotropic flavivirus co-targeted for brain-specific miRNA in ORF and 3′NCR.
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Multiple miRNA co-targeting completely abolishes viral replication in the brain of neonatal mice.
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Simultaneous miRNA co-targeting prevents virus escape and reversion to neurovirulent phenotype.