B-cell memory against factor VIII
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- 作者：Birgit M. Reipert ; birgit.reipert@baxalta.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hemophilia A ; FVIII-specific antibodies ; Neutralizing and non-neutralizing antibodies ; Memory B cells ; Immune regulation
- 刊名：Cellular Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：49-58
- 全文大小：2564 K
文摘
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Neutralizing antibodies against FVIII are high-affinity IgG1 and IgG4 antibodies.
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Memory B cells are essential in maintaining long-lasting antibody responses.
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High FVIII concentrations inhibit restimulation of FVIII-specific memory B cells.