Four chimeric PCV1 viruses expressing known antigenic epitopes of PRRSV were constructed and rescued.
The chimeric viruses were stable and infectious in vitro and three chimeric viruses were infectious in pigs.
The PCV1-VR2385EPI chimeric viruses elicited neutralizing antibodies against PRRSV VR2385 strain.
The non-pathogenic PCV1 potentially may serve as a vaccine delivery vector.