Identification of a variant antigenic neutralizing epitope in hypervariable region 1 of avian leukosis virus subgroup J
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- 作者：Minbo Houa ; 1 ; Defang Zhoua ; 1 ; Gen Lia ; Huijun Guoa ; b ; Jianzhu Liua ; b ; Guihua Wanga ; b ; Qiankun Zhengc ; Ziqiang Chenga ; b ; czqsd@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian leukosis virus subgroup J ; Variant epitope ; Reverse vaccinology.
- 刊名：Vaccine
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：34
- 期：11
- 页码：1399-1404
- 全文大小：1108 K
文摘
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Antibody induced by predicted B-cell multi-epitope protein can neutralize and recognize three different strains of ALV-J.
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A variant antigenic neutralizing epitope was identified using reverse vaccinology methods.
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The founder epitope and its variants can react with all anti-ALV-J sera from field, indicating the potential value for the novel multi-epitope vaccine development.