Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions
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- 作者：Mana Mahapatra ; mana.mahapatra@pirbright.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Bob Statham ; Yanmin Li ; Jef Hammond ; David Paton ; Satya Parida
- 关键词：FMD virus ; Antigenic variation ; Capsid sequence ; Epitopes ; Polyclonal antibodies ; Antigenic determinants
- 刊名：Vaccine
- 出版年：2016
- 出版时间：8 June 2016
- 年：2016
- 卷：34
- 期：27
- 页码：3199-3206
- 全文大小：1286 K
文摘
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The recent A-Iran-05 viruses circulating in the Middle East do not match with the existing vaccines.
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Full capsid sequence of 13 SIS-10 and SIS-12 viruses was generated.
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The r1-values generated using antisera raised against two existing vaccines and a new vaccine.
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Amino acid changes in neutralizing antigenic sites 1, 2 and 4 were observed.