Hypervariable antigenic region 1 of classical swine fever virus E2 protein impacts antibody neutralization
详细信息 查看全文
- 作者：Xun Liao ; Zuohuan Wang ; Tong Cao ; Chao Tong ; Shichao Geng ; Yuanxing Gu ; Yingshan Zhou ; Xiaoliang Li ; Weihuan Fang ; whfang@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Classical swine fever virus ; Epitope mapping ; Chimeric viruses ; Neutralization antibody
- 刊名：Vaccine
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：34
- 期：33
- 页码：3723-3730
- 全文大小：1573 K
文摘
- •
A monoclonal antibody specific for E2 of CSFV isolates of group 2, not of group 1.
- •
This mAb epitope is located in hypervariable antigenic region 1 (HAR1).
- •
Glu713 within this epitope is critical for specific recognition.
- •
Antiserum from vaccine C-strain failed to neutralize group 2 strains.
- •
Antiserum of chimeric C-strain carrying this HAR1 had good cross-neutralizing ability.