Expression of antigenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV) in a modified live-attenuated porcine circovirus type 2 (PCV2) vaccine virus (PCV1-2a) as a potential bivalent vaccine against both PCV2 and PRRSV
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- 作者：Pablo E. Piñ ; eyroa ; b ; Scott P. Kenneya ; Luis G. Gimé ; nez-Lirolab ; C. Lynn Heffrona ; Shannon R. Matzingera ; Tanja Opriessnigb ; c ; Xiang-Jin Menga ; xjmeng@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porcine reproductive and respiratory syndrome virus (PRRSV) ; Porcine circovirus type 2 (PCV2) ; Bivalent modified live-attenuated vaccine (MLV) ; Chimeric PCV1-2 vaccine
- 刊名：Virus Research
- 出版年：2015
- 出版时间：2 December 2015
- 年：2015
- 卷：210
- 期：Complete
- 页码：154-164
- 全文大小：1957 K
文摘
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Insertion of PRRSV epitopes in PCV1-2a vaccine virus did not impair virus infectivity.
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Four chimeric PCV1-2a viruses expressing PRRSV epitopes were successfully rescued.
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Two of the 4 chimeric viruses elicited neutralizing antibodies against PRRSV and PCV2.